Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis.

@article{Donovan2001VirulenceOA,
  title={Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis.},
  author={Michael C. O Donovan and J J Schumuke and William A Fonzi and Sheri L. Bonar and K Gheesling-Mullis and Gary S. Jacob and Vincent Jo Davisson and Stan B Dotson},
  journal={Infection and immunity},
  year={2001},
  volume={69 4},
  pages={2542-8}
}
The relative pathogenicities of three Candida albicans strains differing in the function of ADE2 (the gene encoding phosphoribosylaminoimidazole carboxylase) were evaluated in a murine candidiasis model. C. albicans strain CAI7 (ade2/ade2), previously constructed by site-specific recombination, was avirulent in immunosuppressed mice compared to the parent strain, CAF2-1, and a heterozygous ADE2/ade2 strain obtained by transforming CAI7 with a wild-type allele. The reduced virulence of CAI7 was… CONTINUE READING

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Sequence analysis of the Candida albicans ADE2 gene and physical separation of the two functionally distinct domains of the phosphoribosylaminoimidazole carboxylase

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