Virulence of Streptococcus mutans: in vivo reversion of a low-virulence mutant results in partial displacement and pathogenesis.

@article{Hirasawa1980VirulenceOS,
  title={Virulence of Streptococcus mutans: in vivo reversion of a low-virulence mutant results in partial displacement and pathogenesis.},
  author={Masatomo Hirasawa and Hiroshi Kiyono and James L. Babb and T. Shiota and Suzanne M. Michalek and Jerry R. Mcghee},
  journal={Infection and immunity},
  year={1980},
  volume={27 3},
  pages={1003-11}
}
A mutant of Streptococcus mutans 6715 wild type (WT), designated C4, has been shown previously to be defective in glucosyltransferase synthesis of insoluble glucan and to have low virulence in monoassociated gnotobiotic rats. The present investigation was concerned with the detection of WT-like variants of C4 in monoassociated rats, the supplantation of C4 by these WT-like organisms, and finally, the pathogenic potential of these WT-like organisms in gnotobiotic rats. In the first series of… CONTINUE READING

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