Virulence inhibition by zinc in shiga-toxigenic Escherichia coli.

@article{Crane2011VirulenceIB,
  title={Virulence inhibition by zinc in shiga-toxigenic Escherichia coli.},
  author={John K Crane and Isaac Wyatt Byrd and Edgar C. Boedeker},
  journal={Infection and immunity},
  year={2011},
  volume={79 4},
  pages={1696-705}
}
Previously, our laboratories reported that zinc inhibited expression of several important virulence factors in enteropathogenic Escherichia coli (EPEC) and reduced EPEC-induced intestinal damage in vivo. Since EPEC is genetically related to Shiga-toxigenic E. coli (STEC), we wondered whether the beneficial effects of zinc extended to STEC as well. Treatment options for STEC infection are very limited, since antibiotics tend to exacerbate disease via enhanced toxin production, so a safe… CONTINUE READING

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