Virulence factors in Escherichia coli urinary tract infection

  title={Virulence factors in Escherichia coli urinary tract infection},
  author={J. R. Johnson},
  journal={Clinical Microbiology Reviews},
  pages={80 - 128}
  • J. Johnson
  • Published 1 January 1991
  • Medicine, Biology
  • Clinical Microbiology Reviews
Uropathogenic strains of Escherichia coli are characterized by the expression of distinctive bacterial properties, products, or structures referred to as virulence factors because they help the organism overcome host defenses and colonize or invade the urinary tract. Virulence factors of recognized importance in the pathogenesis of urinary tract infection (UTI) include adhesins (P fimbriae, certain other mannose-resistant adhesins, and type 1 fimbriae), the aerobactin system, hemolysin, K… 

Microbial virulence determinants and the pathogenesis of urinary tract infection.

  • James R. Johnson
  • Biology, Medicine
    Infectious disease clinics of North America
  • 2003

Virulence Factors of Uropathogenic E. coli

Virulence factors located on bacterial surface including capsule and lipopolysaccharides may also have the contribution to UTIs providing antiphagocytosis and antibactericidal complement activity.

Chapter 2 Virulence Factors of Uropathogenic E . coli

In order for a successful infection and creating a satisfactory environment inside the host, strains of uropathogenic Escherichia coli (UPEC) need some special features that are achieved by

Virulence Factors and Innovative Strategies for the Treatment and Control of Uropathogenic Escherichia coli

Key virulence factors of UPEC such as adhesins, toxins, iron acquisition systems, and biofilm formation by UPEC are presented, which are major problems in patients with long-term catheterization.

Urinary tract infections-microbial virulence determinants and reactive oxygen species.

Characterization of Uropathogenic E. coli in relation to virulence Factors

The concept of uropathogenic bacteria refer to certain strains that are selected from faecal flora, not by chance or based on prevalence but because of specific virulence factors, which help them to colonize host mucosal surface and circumvent host defense to allow invasion of the normally sterile urinary tract.

Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports

The aim of this study was to characterize E. coli strains isolated from humans, animals and food for the presence of bacterial genes encoding virulence factors such as toxins, and iron acquisition systems in the context of an increasing spread of ExPEC infections.

Detection of Virulence Markers in Uropathogenic Escherichia coli, their Serotypes and Antibiotic Sensitivity Patterns

The present study showed the expression of virulence factors and multiple drug resistance in E. coli isolated from urinary tract infection.



Aerobactin and other virulence factor genes among strains of Escherichia coli causing urosepsis: association with patient characteristics

The findings suggest that the determinants for aerobactin, P fimbriae, and hemolysin are conserved on the chromosome of the antimicrobial-agent-susceptible uropathogenic strains of E. coli which invade noncompromised patients.

Factors affecting virulence in Escherichia coli urinary tract infections.

The studies suggesting that the K antigen is a significant virulence factor seem to be in conflict with other studies indicating the dominance of certain serotypes of E. coli in the stool and in urinary tract infections.

Hemolysin Production as a Virulence Marker in Symptomatic and Asymptomatic Urinary Tract Infections Caused by Escherichia coli

Potential virulence, as defined by combined levels of adhesion to urinary epithelial cells, serum resistance, and mouse toxicity, was assessed for Escherichia coli strains causing symptomatic and

Urinary tract infectivity or R strains of Escherichia coli carrying various virulence factors.

The virulence factors of Escherichia coli supposed to act in urinary tract infections were studied on R strains in a suckling mouse model and the adhesins, the diffusible haemolysin, and the acidic polysaccharide K antigens are definitely additive virulence Factors in the model.

Genes determining adhesin formation in uropathogenic Escherichia coli.

It is hoped that an increased knowledge about bacterial adhesion will facilitate more rational developments of therapeutic or preventive measures against a given pathogen.

Molecular epidemiology of adhesin and hemolysin virulence factors among uropathogenic Escherichia coli

The distribution of these virulence factors was similar in the presence or absence of reflux, indicating that structural abnormalities of the urinary tract did not facilitate colonization by adhesin-negative isolates.

Contribution of cloned virulence factors from uropathogenic Escherichia coli strains to nephropathogenicity in an experimental rat pyelonephritis model

All three determinants investigated, S fimbriae, serum resistance, and hemolysin, contribute to the multifactorial phenomenon of E. coli nephropathogenicity.

The role of bacterial virulence factors and Tamm-Horsfall protein in the pathogenesis of Escherichia coli urinary tract infection in infants.

With the exception of hemagglutination properties and certain pyelonephritogenic O serotypes, other virulence factors of E coli could not be defined in the infant population and the role of THP, if any, in the pathogenesis of UTI remains unresolved.

Uropathogenic properties of Escherichia coli in recurrent urinary-tract infection.

Strains rich in pathogenic properties were more commonly isolated from upper urinary-tract infections than from lower-t tract infections; this indicates that the properties of the invading organism may influence the localisation of infection.

Hemolytic Escherichia coli strains in the human fecal flora as potential urinary pathogens.

  • J. HackerG. SchröterA. SchrettenbrunnerC. HughesW. Goebel
  • Medicine, Biology
    Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...
  • 1983