Virulence factors determine attachment and ingestion of nonopsonized and opsonized Bordetella pertussis by human monocytes.

@article{Hazenbos1994VirulenceFD,
  title={Virulence factors determine attachment and ingestion of nonopsonized and opsonized Bordetella pertussis by human monocytes.},
  author={Wouter L. W. Hazenbos and Bernard van den Berg and Jan W van't Wout and Frits R. Mooi and Ralph van Furth},
  journal={Infection and immunity},
  year={1994},
  volume={62 11},
  pages={
          4818-24
        }
}
In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells attached to monocytes. Nonopsonized B. pertussis mutant strains deficient in filamentous hemagglutinin, fimbriae, or pertactin exhibited a reduced adherence to monocytes compared… CONTINUE READING

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