Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.

Abstract

UNLABELLED The nonstructural protein NSs is the main virulence factor of Rift Valley fever virus (RVFV; family Bunyaviridae, genus Phlebovirus), a serious pathogen of livestock and humans in Africa. RVFV NSs blocks transcriptional upregulation of antiviral type I interferons (IFN) and destroys the general transcription factor TFIIH subunit p62 via the… (More)
DOI: 10.1128/JVI.02914-13

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Cite this paper

@article{Kainulainen2014VirulenceFN, title={Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.}, author={Markus Kainulainen and Matthias Habjan and Philipp Hubel and Laura Busch and Simone Lau and Jacques Colinge and Giulio Superti-Furga and Andreas Pichlmair and Friedemann Weber}, journal={Journal of virology}, year={2014}, volume={88 6}, pages={3464-73} }