Virulence and transmission success of the malarial parasite Plasmodium falciparum.

@article{Hayward1999VirulenceAT,
  title={Virulence and transmission success of the malarial parasite Plasmodium falciparum.},
  author={Rhian E. Hayward and Bela Tiwari and Karen P Piper and Dror I. Baruch and Karen P. Day},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 8},
  pages={4563-8}
}
Virulence of Plasmodium falciparum is associated with the expression of variant surface antigens designated PfEMP1 (P. falciparum erythrocyte membrane protein 1) that are encoded by a family of var genes. Data presented show that the transmission stages of P. falciparum also express PfEMP1 variants. Virulence in this host-parasite system can be considered a variable outcome of optimizing the production of sexual transmission stages from the population of disease-inducing asexual stages… CONTINUE READING