Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics.

@article{Holzmuller2008VirulenceAP,
  title={Virulence and pathogenicity patterns of Trypanosoma brucei gambiense field isolates in experimentally infected mouse: differences in host immune response modulation by secretome and proteomics.},
  author={Philippe Holzmuller and David Georges Biron and Pierrette Courtois and Mathurin Koffi and Rachel Bras-Gonçalves and Sylvie Daulou{\`e}de and Philippe Solano and G{\'e}rard Cuny and Philippe Vincendeau and Vincent Jamonneau},
  journal={Microbes and infection},
  year={2008},
  volume={10 1},
  pages={79-86}
}
Human African trypanosomiasis is characterised by an important clinical diversity. Although Trypanosoma brucei gambiense field stocks isolated from patients in the same focus did not exhibit apparent genetic variability, they showed marked differences in terms of virulence (capacity to multiply inside a host) and pathogenicity (ability of producing mortality) in experimental murine infections. Two strains exhibiting opposite pathogenic and virulence properties in mouse were further investigated… CONTINUE READING