Virulence Factors Produced by Staphylococcus aureus Biofilms Have a Moonlighting Function Contributing to Biofilm Integrity.

@article{Graf2019VirulenceFP,
  title={Virulence Factors Produced by Staphylococcus aureus Biofilms Have a Moonlighting Function Contributing to Biofilm Integrity.},
  author={Alexander Christian Graf and Anne S. Leonard and Manuel Sch{\"a}uble and Lisa M Rieckmann and Juliane Hoyer and Sandra Maa{\ss} and Michael Lalk and D{\"o}rte Becher and Jan Pan{\'e}-Farr{\'e} and Katharina Riedel},
  journal={Molecular & cellular proteomics : MCP},
  year={2019},
  volume={18 6},
  pages={
          1036-1053
        }
}
Staphylococcus aureus is the causative agent of various biofilm-associated infections in humans causing major healthcare problems worldwide. This type of infection is inherently difficult to treat because of a reduced metabolic activity of biofilm-embedded cells and the protective nature of a surrounding extracellular matrix (ECM). However, little is known about S. aureus biofilm physiology and the proteinaceous composition of the ECM. Thus, we cultivated S. aureus biofilms in a flow system and… CONTINUE READING
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