Virulence, immunopathology and transmissibility of selected strains of Mycobacterium tuberculosis in a murine model.

@article{MarquinaCastillo2009VirulenceIA,
  title={Virulence, immunopathology and transmissibility of selected strains of Mycobacterium tuberculosis in a murine model.},
  author={Brenda Marquina-Castillo and Lourdes Garc{\'i}a-Garc{\'i}a and Alfredo Ponce-de-Le{\'o}n and Mar{\'i}a-Eugenia Jim{\'e}nez-Corona and Miriam Bobadilla-Del Valle and Bulmaro Cano-Arellano and Sergio Canizales-Quintero and Areli Mart{\'i}nez-Gamboa and Midori Kato-Maeda and Brian Robertson and Douglas Young and Peter Small and Gary Schoolnik and Jos{\'e} Sifuentes-Osornio and Rogelio E Hern{\'a}ndez-Pando},
  journal={Immunology},
  year={2009},
  volume={128 1},
  pages={123-33}
}
After encounter with Mycobacterium tuberculosis, a series of non-uniform immune responses are triggered that define the course of the infection. Eight M. tuberculosis strains were selected from a prospective population-based study of pulmonary tuberculosis patients (1995-2003) based on relevant clinical/epidemiological patterns and tested in a well-characterized BALB/c mouse model of progressive pulmonary tuberculosis. In addition, a new mouse model of transmissibility consisting of prolonged… CONTINUE READING

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