Virucidal activities of medium- and long-chain fatty alcohols and lipids against respiratory syncytial virus and parainfluenza virus type 2: comparison at different pH levels

@article{Hilmarsson2007VirucidalAO,
  title={Virucidal activities of medium- and long-chain fatty alcohols and lipids against respiratory syncytial virus and parainfluenza virus type 2: comparison at different pH levels},
  author={Hilmar Hilmarsson and Bergthor Traustason and Thordis Kristmundsdottir and Halld{\'o}r Thormar},
  journal={Archives of Virology},
  year={2007},
  volume={152},
  pages={2225-2236}
}
SummaryRecent studies have shown that some lipids and fatty alcohols have microbicidal activities against a broad variety of pathogens. In this study, virucidal activities of fatty acids, monoglycerides and fatty alcohols were tested against respiratory syncytial virus (RSV) and human parainfluenza virus type 2 (HPIV2) at different concentrations, times and pH levels. The most active compounds were mixed with milk products and fruit juices and the mixtures tested for virucidal effects. The aim… 
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References

SHOWING 1-10 OF 37 REFERENCES
Virucidal activities of medium‐ and long‐chain fatty alcohols, fatty acids and monoglycerides against herpes simplex virus types 1 and 2: comparison at different pH levels
TLDR
In most cases HLB numbers cannot explain the different virucidal activities of fatty alcohols and lipids, particularly not their increased activity at low pH, it is more likely that the acidic environment makes HSV more sensitive, possibly by ionic changes in the envelope proteins.
Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides
TLDR
Studies are needed to establish whether human milk lipids have an antimicrobial effect in the stomach and intestines of infants and to determine what role, if any, they play in protecting infants against gastrointestinal infections.
Effects of polysorbates on antiviral and antibacterial activity of monoglyceride in pharmaceutical formulations.
TLDR
This work evaluated the effect of polysorbates 20 and 40 at different concentrations on the microbicidal activity of monocaprin formulated either in a hydrogel or in a solution, using propylene glycol as co-solvent and glycofurol 75 as carrier.
Antimicrobial effects of lipids
TLDR
Hydrogel formulations have been developed which contain monocaprin as the microbicidal ingredient and which kill the above pathogens in large numbers within 1 to 10 min in vitro, and may be useful in counteracting sexually transmitted infections, including HIV infection, as well as for treatment of infections of skin and mucosa.
Inactivation of Lipid-Containing Viruses by Long-Chain Alcohols
TLDR
The findings suggest that dodecanol, tetradecanol, and phytol may warrant further studies as potential antiviral agents, particularly for topical application to virus-infected areas of the skin.
Development and evaluation of microbicidal hydrogels containing monoglyceride as the active ingredient.
TLDR
The aim was to find which lipid would be preferable as the active ingredient in a virucidal hydrogel formulation for the purpose of preventing transmission of pathogens to mucosal membranes, particularly sexually transmitted viruses, and bacteria.
Inactivation of Visna Virus and Other Enveloped Viruses by Free Fatty Acids and Monoglycerides
TLDR
Human milk was found to become antiviral during storage at 4 degrees C because of the release of fatty acids by lipolysis, and lipids commonly found in natural products could possibly be used as antiviral agents against enveloped viruses.
Inactivation and Inhibition of Replication of the Enveloped Bacteriophage φ6 by Fatty Acids
  • J. Sands
  • Medicine, Biology
    Antimicrobial Agents and Chemotherapy
  • 1977
TLDR
It is concluded that the fatty acids that prevent φ6 replication probably do so by interfering with the entry of the viral genome into the host cell.
Inactivation of Enveloped Viruses in Human Bodily Fluids by Purified Lipids a
TLDR
Preliminary studies indicate thatlipids decrease sperm motility and viability suggesting that lipids may potentially be used as combination spermicidal and virucidal agents.
Stable Concentrated Emulsions of the 1-Monoglyceride of Capric Acid (Monocaprin) with Microbicidal Activities against the Food-Borne Bacteria Campylobacter jejuni, Salmonella spp., and Escherichia coli
TLDR
Emulsions of monocaprin killed a variety of Campylobacter isolates from humans and poultry and also killed strains of Campyobacter coli and Campyloblacter lari, indicating a broad anticampylobacteria activity.
...
1
2
3
4
...