Virtual screening leads to the discovery of an effective antagonist of lymphocyte function-associated antigen-1.

@article{Shoda2007VirtualSL,
  title={Virtual screening leads to the discovery of an effective antagonist of lymphocyte function-associated antigen-1.},
  author={Miyuki Shoda and Takeo Harada and Kazuo Yano and Florence L. Stahura and Takeshi Himeno and Satoshi Shiojiri and Yuji Kogami and Hiroyuki Kouji and J{\"u}rgen Bajorath},
  journal={ChemMedChem},
  year={2007},
  volume={2 4},
  pages={515-21}
}
The binding of lymphocyte function-associated antigen-1 (LFA-1) to its ligand on endothelial cells, intercellular adhesion molecule-1 (ICAM-1), is a crucial step in the migration of leukocytes during the early stages of inflammation and is also involved in T-cell activation. In this paper, we report the identification of a series of novel antagonists of the… CONTINUE READING