Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa

@article{Zeng2008VirtualSF,
  title={Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa},
  author={Zhirui Zeng and Li Qian and Lixiang Cao and Hongming Tan and Yali Huang and Xiaoli Xue and Yong Hang Shen and Shining Zhou},
  journal={Applied Microbiology and Biotechnology},
  year={2008},
  volume={79},
  pages={119-126}
}
The automated docking program DOCK 5.3.0 was applied to screening for quorum sensing inhibitors (QSIs) of Peudomonus aeruginosa from a database containing 51 active components of Traditional Chinese Medicines with antibacterial activity. Five potential QSIs were revealed by the computer-based virtual screening. The compounds 3, 4, 5, 6, 7 inhibit biofilm formation of P. aeruginosa at a concentration of 200 μM. Compound 4 (baicalein) does not inhibit the growth of P. aeruginosa; however, it… CONTINUE READING

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