Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa

@article{Zeng2008VirtualSF,
  title={Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa},
  author={Z. Zeng and Li Qian and L. Cao and H. Tan and Yali Huang and Xiaoli Xue and Yong Shen and Shining Zhou},
  journal={Applied Microbiology and Biotechnology},
  year={2008},
  volume={79},
  pages={119-126}
}
The automated docking program DOCK 5.3.0 was applied to screening for quorum sensing inhibitors (QSIs) of Peudomonus aeruginosa from a database containing 51 active components of Traditional Chinese Medicines with antibacterial activity. Five potential QSIs were revealed by the computer-based virtual screening. The compounds 3, 4, 5, 6, 7 inhibit biofilm formation of P. aeruginosa at a concentration of 200 μM. Compound 4 (baicalein) does not inhibit the growth of P. aeruginosa; however, it… Expand
Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.
Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector.
Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors
Quorum-sensing inhibitors as anti-pathogenic drugs.
Identity and effects of quorum-sensing inhibitors produced by Penicillium species.
Inhibition of Vibrio biofilm formation by a marine actinomycete strain A66
Remarkable Synergies between Baicalein and Tetracycline, and Baicalein and β‐Lactams against Methicillin‐Resistant Staphylococcus aureus
Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms.
  • M. Parsek, E. Greenberg
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2000
Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover.
...
1
2
3
...