Virtual screening based on pharmacophoric features of known calpain inhibitors to identify potent inhibitors of calpain

Abstract

Calpain, a member of the group of cysteine protease enzymes, has been recognized as a promising drug target for several diseases, including cataract. In the present study, an attempt was made to identify potential inhibitors of calpain by employing a pharmacophore-based virtual screening and docking approach. A knowledge-based 3D pharmacophore model was… (More)
DOI: 10.1007/s00044-013-0842-7

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