Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

@inproceedings{Moffitt2015VirtualMI,
  title={Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma},
  author={Richard A Moffitt and Raoud Marayati and Elizabeth L Flate and Keith E. Volmar and S Gabriela Herrera Loeza and Katherine A Hoadley and Naim U. Rashid and Lindsay A Williams and Samuel C Eaton and Alexander Q. H. Chung and Jadwiga K Smyla and Judy M. Anderson and Hong Jin Kim and David J. Bentrem and Mark S. Talamonti and Christine A Iacobuzio-Donahue and Michael Anthony Hollingsworth and Jen Jen J. Yeh},
  booktitle={Nature Genetics},
  year={2015}
}
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes capturing precise tumor-specific molecular information difficult. Here we have overcome this problem by applying blind source separation to a diverse collection of PDAC gene expression microarray data, including data from primary tumor, metastatic and normal samples. By digitally separating tumor, stromal and normal gene… CONTINUE READING
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