Virtual Screening Against α-Cobratoxin

@article{Utsintong2009VirtualSA,
  title={Virtual Screening Against α-Cobratoxin},
  author={M. Utsintong and T. Talley and P. W. Taylor and A. Olson and O. Vajragupta},
  journal={Journal of Biomolecular Screening},
  year={2009},
  volume={14},
  pages={1109 - 1118}
}
α-Cobratoxin (Cbtx), the neurotoxin isolated from the venom of the Thai cobra Naja kaouthia , causes paralysis by preventing acetylcholine (ACh) binding to nicotinic acetylcholine receptors (nAChRs). In the current study, the region of the Cbtx molecule that is directly involved in binding to nAChRs is used as the target for anticobratoxin drug design. The crystal structure (1YI5) of Cbtx in complex with the acetylcholine binding protein (AChBP), a soluble homolog of the extracellular binding… Expand
23 Citations
Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins.
Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures.
Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins
Potential interaction of natural dietary bioactive compounds with COX-2.
...
1
2
3
...

References

SHOWING 1-10 OF 29 REFERENCES
Three-dimensional structure of the "long" neurotoxin from cobra venom.
Weak neurotoxin from Naja kaouthia cobra venom affects haemodynamic regulation by acting on acetylcholine receptors.
Immunochemical and biochemical comparisons of equine monovalent and polyvalent snake antivenoms.
Structural and Ligand Recognition Characteristics of an Acetylcholine-binding Protein from Aplysia californica*
Large-scale virtual screening for discovering leads in the postgenomic era
...
1
2
3
...