Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes

@inproceedings{Worth2017VirtualCB,
  title={Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes},
  author={Andrew P. Worth and Jochem Louisse and Peter Macko and J. V. Sala Benito and Alicia Paini},
  booktitle={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2017}
}
In order to replace the use of animals in toxicity testing, there is a need to predict human in vivo toxic doses from concentrations that cause adverse effects in in vitro test systems. The virtual cell based assay (VCBA) has been developed to simulate intracellular concentrations as a function of time, and can be used to interpret in vitro concentration-response curves. In this study we refine and extend the VCBA model by including additional target-organ cell models and by simulating the fate… CONTINUE READING