Virotherapy clinical trials for regional disease: In situ immune modulation using recombinant poxvirus vectors

@article{Mastrangelo2002VirotherapyCT,
  title={Virotherapy clinical trials for regional disease: In situ immune modulation using recombinant poxvirus vectors},
  author={Michael J. Mastrangelo and Edmund C. Lattime},
  journal={Cancer Gene Therapy},
  year={2002},
  volume={9},
  pages={1013-1021}
}
The ability of viruses to readily infect tumor cells both in vitro and in vivo has resulted in their study as antitumor agents through a variety of strategies. Replicating and conditionally replicating viruses and recombinant viruses encoding genes for toxins and/or prodrugs have been studied for their direct antitumor activity with promising results. However, to date, the lack of a targettable construct able to localize to all tumors following systemic administration has proven to be a major… CONTINUE READING
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