Viroporins: structure and biological functions

  title={Viroporins: structure and biological functions},
  author={Jos{\'e} Luis Nieva and Vanesa Madan and Luis Carrasco},
  journal={Nature Reviews Microbiology},
Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically relevant animal viruses. When these proteins oligomerize in host cell membranes, they form hydrophilic pores that disrupt a number of physiological properties of the cell. Viroporins are crucial for viral pathogenicity owing to their involvement in several diverse steps of the viral life cycle. Thus, these viral proteins, which include influenza A virus matrix protein 2 (M2), HIV-1 viral protein U (Vpu… CONTINUE READING
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