Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses

@article{Lowenstein2003VirologyAI,
  title={Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses},
  author={P R Lowenstein},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={933-934}
}
The conversion of pathogenic viruses into vectors for therapeutic genes is avowedly a simple idea. Any virus is a potential vector for gene delivery if two simple maneuvers can be completed: the elimination of virus replication (or, its capacity to cause disease), and the insertion of a gene of interest (or, its capacity to deliver a therapeutic gene). These two maneuvers have now been accomplished for many viruses, both in experimental paradigms and in clinical trials. However, one impediment… CONTINUE READING