Virological and immunological features of active cytomegalovirus infection in nonimmunosuppressed patients in a surgical and trauma intensive care unit.

@article{Chilet2010VirologicalAI,
  title={Virological and immunological features of active cytomegalovirus infection in nonimmunosuppressed patients in a surgical and trauma intensive care unit.},
  author={Marifina Chilet and Gerardo Aguilar and Isabel Benet and Javier Gil Belda and Nuria Tormo and Jos{\'e} Antonio Carbonell and Mar{\'i}a Angeles Clari and Elisa Costa and David Navarro},
  journal={Journal of medical virology},
  year={2010},
  volume={82 8},
  pages={1384-91}
}
Cytomegalovirus (CMV) reactivation occurs frequently in critically ill patients. The natural course of CMV infection and the interaction between CMV and the adaptive immune system in this setting remain poorly defined. Fifty-three CMV-seropositive patients in a surgical and trauma intensive care unit were included in this study. The CMV DNA load in tracheal aspirates (TA) and plasma (PL) was monitored by qPCR. CMV-specific T-cell immunity was assessed by intracellular cytokine staining. Plasma… CONTINUE READING

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