Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010 / 11

@inproceedings{Baldanti2011VirologicalAO,
  title={Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010 / 11},
  author={Fausto Baldanti and Alessandro Zanetti},
  year={2011}
}
An enhanced binding affinity of the mutated haemagglutinin to the α-2,3 sialic acid receptor rather than to the α-2,6 sialic acid receptor has been postulated to be the basis of the increased virulence of D222G/N mutants [3]. The α-2,3 sialic acid receptor is present at higher density on the surface of the cells of the lower respiratory tract tissues whereas the α-2,6 sialic acid receptor is present at higher density on the surface of cells of the upper respiratory tract tissues.