Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection.

@article{Osinusi2015VirologicRF,
  title={Virologic response following combined ledipasvir and sofosbuvir administration in patients with HCV genotype 1 and HIV co-infection.},
  author={Anu O Osinusi and Kerry Townsend and Anita R Kohli and Amy K Nelson and Cassie Seamon and Eric G Meissner and Dimitra Bon and Rachel Silk and Chloe Gross and Angie Price and Mohammad Mohseni Sajadi and Sreetha Sidharthan and Zayani Sims and Eva Herrmann and John M. Hogan and Gebeyehu Teferi and Rohit Talwani and Michael A Proschan and Veronica Jenkins and David E Kleiner and Brad J Wood and G. M. Subramanian and Phillip S. Pang and John McHutchison and Michael A. Polis and Anthony S. Fauci and Henry Masur and Shyamasundaran Kottilil},
  journal={JAMA},
  year={2015},
  volume={313 12},
  pages={1232-9}
}
IMPORTANCE There is an unmet need for interferon- and ribavirin-free treatment for chronic hepatitis C virus (HCV) infection in patients co-infected with human immunodeficiency virus (HIV). OBJECTIVE To evaluate the rates of sustained virologic response (SVR) and adverse events in previously untreated patients with HCV genotype 1 and HIV co-infection following a 12-week treatment of the fixed-dose combination of ledipasvir and sofosbuvir. DESIGN, SETTING, AND PARTICIPANTS Open-label, single… CONTINUE READING
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