Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of T cells.

@article{Derse1995VirionsRF,
  title={Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of T cells.},
  author={David Derse and Judy A. Mikovits and Maria Polianova and Barbara K Felber and F Ruscetti},
  journal={Journal of virology},
  year={1995},
  volume={69 3},
  pages={
          1907-12
        }
}
The ability of molecular clones of human T-cell leukemia virus type I (HTLV-I) to direct the synthesis of infectious virions has not previously been demonstrated. An HTLV-I provirus originating from an adult T-cell leukemia patient was cloned into a plasmid vector and is designated pCS-HTLV. This molecular clone was shown to direct the synthesis of viral mRNA and proteins in transiently transfected cells; in addition, virus structural proteins were released into the culture medium. Viral… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 25 CITATIONS

Animal Models Utilized in HTLV-1 Research

Amanda R Panfil, Jacob J Al-Saleem, Patrick L Green
  • Virology : research and treatment
  • 2013

David D. Derse, 1949-2009

  • Retrovirology
  • 2009
VIEW 1 EXCERPT

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
VIEW 1 EXCERPT