Virion-associated, host-derived DHX9/RNA helicase A enhances the processivity of HIV-1 reverse transcriptase on genomic RNA

@article{Brady2019VirionassociatedHD,
  title={Virion-associated, host-derived DHX9/RNA helicase A enhances the processivity of HIV-1 reverse transcriptase on genomic RNA},
  author={S. Brady and Gatikrushna Singh and Cheryl Bolinger and Z. Song and I. Boeraş and Kexin Weng and Bria Trent and W. C. Brown and Kamalendra Singh and K. Boris-Lawrie and X. Heng},
  journal={The Journal of Biological Chemistry},
  year={2019},
  volume={294},
  pages={11473 - 11485}
}
DHX9/RNA helicase A (RHA) is a host RNA helicase that participates in many critical steps of the HIV-1 life cycle. It co-assembles with the viral RNA genome into the capsid core. Virions deficient in RHA are less infectious as a result of reduced reverse transcription efficiency, demonstrating that the virion-associated RHA promotes reverse transcription before the virion gains access to the new host's RHA. Here, we quantified reverse-transcription intermediates in HIV-1–infected T cells to… Expand
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