Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells.

@article{Dvoriantchikova2016VirallyDC,
  title={Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells.},
  author={Galina Dvoriantchikova and Steve Pappas and Xueting Luo and M{\'a}rcio Ribeiro and Dagmara Danek and Daniel Valerio Pel{\'a}ez and Kevin Kiwon Park and Dmitry Ivanov},
  journal={The European journal of neuroscience},
  year={2016},
  volume={44 11},
  pages={2935-2943}
}
As axon damage and retinal ganglion cell (RGC) loss lead to blindness, therapies that increase RGC survival and axon regrowth have direct clinical relevance. Given that NFκB signaling is critical for neuronal survival and may regulate neurite growth, we investigated the therapeutic potential of NFκB signaling in RGC survival and axon regeneration. Although both NFκB subunits (p65 and p50) are present in RGCs, p65 exists in an inactive (unphosphorylated) state when RGCs are subjected to… CONTINUE READING
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