Viral vector mediated continuous expression of interleukin-10 in DRG alleviates pain in type 1 diabetic animals.

@article{Thakur2016ViralVM,
  title={Viral vector mediated continuous expression of interleukin-10 in DRG alleviates pain in type 1 diabetic animals.},
  author={Vikram Singh Thakur and Mayra Sanchez Gonzalez and Kristen Pennington and Munmun Chattopadhyay},
  journal={Molecular and cellular neurosciences},
  year={2016},
  volume={72},
  pages={46-53}
}
Painful diabetic neuropathy is a common and difficult to treat complication of diabetes. A growing body of evidence implicates the role of inflammatory mediators in the damage to the peripheral axons and in the pathogenesis of neuropathic pain. Increased expression of pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α in the peripheral nervous system suggests the possibility of change in pain perception in diabetes. In this study we investigated that… CONTINUE READING