Viral vector delivery in solid-state vehicles: gene expression in a murine prostate cancer model.

@article{Siemens2000ViralVD,
  title={Viral vector delivery in solid-state vehicles: gene expression in a murine prostate cancer model.},
  author={D. Robert Siemens and Johanna Austin and Sean P. Hedican and James Tartaglia and Timothy L Ratliff},
  journal={Journal of the National Cancer Institute},
  year={2000},
  volume={92 5},
  pages={403-12}
}
BACKGROUND Although there are increasingly more clinical trials involving gene therapy, efficient gene transfer remains a major hurdle to success. To enhance the efficiency of delivery of viral vectors in gene therapy protocols, we evaluated the effect of various matrices to act as a vehicle for recombinant virus during intratumoral injection. METHODS The ability of several vehicles (catgut spacer, polyglycolic acid, chromic catgut, and gelatin sponge matrix) to deliver the canarypox virus… CONTINUE READING
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