Viral variant nucleotide sequences help expose leukocytic positioning in the JC virus pathway to the CNS.

@article{Jensen1999ViralVN,
  title={Viral variant nucleotide sequences help expose leukocytic positioning in the JC virus pathway to the CNS.},
  author={Peter Neergaard Jensen and Eugene O. Major},
  journal={Journal of leukocyte biology},
  year={1999},
  volume={65 4},
  pages={428-38}
}
The human polyomavirus JCV lytically infects oligodendrocytes of immunosuppressed individuals leading to the fatal demyelinating disease termed progressive multifocal leukoencephalopathy (PML). Dementia, hemiparesis, and hemianopsia are the predominant presenting signs of PML. Asymptomatic JCV infection is common worldwide with approximately 80% of adults testing positive for JCV antibodies. In addition to the brain, JCV has been shown to infect tonsil, lymphoid, bone marrow, and kidney tissues… CONTINUE READING