Viral symbiosis and the holobiontic nature of the human genome.

Abstract

The human genome is a holobiontic union of the mammalian nuclear genome, the mitochondrial genome and large numbers of endogenized retroviral genomes. This article defines and explores this symbiogenetic pattern of evolution, looking at the implications for human genetics, epigenetics, embryogenesis, physiology and the pathogenesis of inborn errors of… (More)
DOI: 10.1111/apm.12488

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