Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion.

@article{Tokitou1999ViralSI,
  title={Viral ski inhibits retinoblastoma protein (Rb)-mediated transcriptional repression in a dominant negative fashion.},
  author={F Tokitou and Teruaki Nomura and Md Matiullah Khan and Sunil C. Kaul and Renu Wadhwa and Takashi Yasukawa and Ichiro Kohno and Shunsuke Ishii},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 8},
  pages={4485-8}
}
The mechanism by which the viral oncogene ski (v-ski) transforms chicken embryo fibroblasts is currently unknown. Recently, the c-ski gene product (c-Ski) was found to bind to N-CoR (nuclear hormone receptor co-repressor), an element implicated in transcriptional repression mediated by multiple transcriptional repressors including the nuclear hormone receptors and Mad. c-Ski is required for transcriptional repression mediated by Mad involved in negative regulation of cellular proliferation. v… CONTINUE READING

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