Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus

@article{Fu1998ViralSE,
  title={Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus},
  author={Yuchang Fu and Yibin Wang and Sylvia M. Evans},
  journal={Nature Biotechnology},
  year={1998},
  volume={16},
  pages={253-257}
}
Expression of transgenes within a single generation by direct DNA injection into vertebrate embryos has been plagued by inefficient and nonuniform gene expression. We report a novel strategy for efficient and stable expression of transgenes driven by both ubiquitous and tissue-specific promoters by direct DNA injection into developing Xenopus laevis embryos. This strategy involves flanking expression cassettes of interest with inverted terminal repeat sequences (ITRs) from adeno-associated… CONTINUE READING

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