Viral sensors: diversity in pathogen recognition.

  title={Viral sensors: diversity in pathogen recognition.},
  author={Stephen A. McCartney and Marco Colonna},
  journal={Immunological reviews},
  volume={227 1},
Innate sensors of viral infection detect viral products and initiate the signal cascades that lead to the antiviral response. Several proteins have been identified to play a role in this process, mostly members of the Toll-like receptor and retinoic acid-inducible gene I-like receptor families. These receptors have been demonstrated to function in part by recognizing a diverse yet unique repertoire of nucleic acid substrates. Upon recognition of their ligands, these sensors activate distinct… CONTINUE READING