Viral resistance patterns selected by antiretroviral drugs and their potential to guide treatment choice.

@article{Moyle1997ViralRP,
  title={Viral resistance patterns selected by antiretroviral drugs and their potential to guide treatment choice.},
  author={Graeme J. Moyle},
  journal={Expert opinion on investigational drugs},
  year={1997},
  volume={6 8},
  pages={943-64}
}
Massive viral turnover and reverse transcriptase's high error rate create the potential for drug-resistant viral variants to appear rapidly under the selective pressure of antiretroviral therapy. Loss of antiviral effect in treatment-adherent persons is most commonly coincident with the appearance of viral mutants with reduced drug sensitivity. Thus, detection of viral resistance may represent an early marker of therapy failure. Similarly, control of viral replication in the plasma compartment… CONTINUE READING