Viral replication and host gene expression in alveolar macrophages infected with Ebola virus (Zaire strain).

@article{Gibb2002ViralRA,
  title={Viral replication and host gene expression in alveolar macrophages infected with Ebola virus (Zaire strain).},
  author={Tammy R Gibb and David A Norwood and Neal Woollen and Erik A. Henchal},
  journal={Clinical and diagnostic laboratory immunology},
  year={2002},
  volume={9 1},
  pages={19-27}
}
In order to characterize the cellular response to and identify potential diagnostic markers for the early detection of Ebola virus, an in vitro culture system involving nonhuman primate alveolar macrophages was developed. Ebola virus replication in the alveolar macrophages was characterized by plaque assay, immunohistochemical analysis, and in situ hybridization. Fluorogenic 5'-nuclease assays specific for nonhuman primate proinflammatory cytokines and chemokines were designed and used to… CONTINUE READING
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