Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters.

@article{Patel2009ViralRR,
  title={Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters.},
  author={Niraj C Patel and Steven J Halvorson and Vojtech Sroller and Amy S. Arrington and Connie H Wong and Elliot O'brian Smith and Regis A. Vilchez and Janet S Butel},
  journal={Virology},
  year={2009},
  volume={386 1},
  pages={
          94-101
        }
}
Viral strain differences influence the oncogenic potential of polyomavirus simian virus 40 (SV40). We hypothesized that viral strain differences might also affect vertical transmission of SV40 in susceptible hosts. Pregnant Syrian golden hamsters were inoculated intraperitoneally with 10(7) plaque-forming units of SV40 and offspring were sacrificed post-delivery (1-21 days, 6 months). Organ extracts were analyzed for SV40 DNA by polymerase chain reaction assay. Transmission of SV40 from mother… CONTINUE READING

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