Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis.

@article{Zaragoza2006ViralPC,
  title={Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis.},
  author={Carlos Zaragoza and Marta Saura and Elizaveta Padalko and Ester Lopez-Rivera and Tania R. Lizarbe and Santiago Lamas and Charles J Lowenstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 50},
  pages={19051-6}
}
Apoptosis is an innate immune response to viral infection that limits viral replication. However, the mechanisms by which cells detect viral infection and activate apoptosis are not completely understood. We now show that during Coxsackievirus infection, the viral protease 3C(pro) cleaves inhibitor of kappaBalpha (IkappaBalpha). A proteolytic fragment of… CONTINUE READING