Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.

@article{Spear2015ViralPP,
  title={Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex.},
  author={Allyn R Spear and Sushma A Ogram and B Joan Morasco and Lucia Eisner Smerage and James Bert Flanegan},
  journal={Virology},
  year={2015},
  volume={485},
  pages={492-501}
}
The differential use of protein precursors and their products is a key strategy used during poliovirus replication. To characterize the role of protein precursors during replication, we examined the complementation profiles of mutants that inhibited 3D polymerase or 3C-RNA binding activity. We showed that 3D entered the replication complex in the form of… CONTINUE READING