Viral pathogenesis of hepatocellular carcinoma in the United States.

  title={Viral pathogenesis of hepatocellular carcinoma in the United States.},
  author={T. Jake Liang and Lennox J. Jeffers and K Rajender Reddy and Maria D de Medina and Isabella Parker and Hugo Cheinquer and V Idrovo and Alfredo A. Rabassa and Eugene R Schiff},
  volume={18 6},
Chronic hepatitis B virus infection is closely associated with the development of hepatocellular carcinoma, which is a major cause of cancer death worldwide. Recent studies have implicated hepatitis C virus infection as a major pathogenic agent of HBsAg-negative hepatocellular carcinoma. The significance of hepatitis C virus and hepatitis B virus infections in the occurrence of HBsAg-negative hepatocellular carcinoma has not been well established in the United States. We studied 91 HBsAg… CONTINUE READING