Viral particles induce Ia antigen expression on astrocytes

  title={Viral particles induce Ia antigen expression on astrocytes},
  author={Paul T. Massa and Ruediger Doerries and V. ter Meulen},
Recent studies have shown that gamma-interferon (IFN-gamma) induces the expression of Ia antigen on astrocytes. This observation is of immunological significance because such activated astrocytes can act as antigen-presenting cells, as demonstrated with myelin basic protein for antigen-specific encephalitogenic T-cell lines. However, the lack of lymphatic drainage in brain and the presence of the so-called blood-brain barrier restricting traffic of cells and macromolecules suggests that IFN… CONTINUE READING
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