Viral oncogenes as tools to study replicative senescence of human cells.

Abstract

Human aging is correlated with reduced proliferation of various cell types, a phenomenon that can be reproduced in in vitro models of replicative senescence. We study senescence of several human primary cell types by analysis of age-related changes in gene expression and gene function. In a second approach, my group uses immortalizing oncogenes derived from… (More)

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