Viral neuroinvasion and encephalitis induced by lipopolysaccharide and its mediators

  title={Viral neuroinvasion and encephalitis induced by lipopolysaccharide and its mediators},
  author={Shlomo Lustig and Haim Danenberg and Yariv Kafri and David Kobiler and David Ben-Nathan},
  journal={The Journal of Experimental Medicine},
  pages={707 - 712}
The present study was designed to test the effect of bacterial endotoxin on penetration of viruses into the central nervous system (CNS). As a model we used two neurovirulent viruses that lack neuroinvasive capacity: West Nile virus-25 (WN-25) and neuroadapted Sindbis virus (SVN). Administration of lipopolysaccharide (LPS, 100 micrograms/mouse) to CD-1 mice, followed by WN-25 inoculation resulted in 83% encephalitis and death, compared with less than 5% in controls. The results in SVN… CONTINUE READING
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Antigenic structure and function of the flavirus envelope protein E. In New Aspects of PositiveStrand RNA Viruses

  • F. X. Heinz, C. Mandl, H. Holtzmann, F. Quirakhoo, W. Tuma, C. Kuntz
  • American Society for Microbiology,
  • 1990
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