Viral nervous necrosis virus persistently replicates in the central nervous system of asymptomatic gilthead seabream and promotes a transient inflammatory response followed by the infiltration of IgM+ B lymphocytes.

@article{LpezMuoz2012ViralNN,
  title={Viral nervous necrosis virus persistently replicates in the central nervous system of asymptomatic gilthead seabream and promotes a transient inflammatory response followed by the infiltration of IgM+ B lymphocytes.},
  author={Azucena L{\'o}pez-Mu{\~n}oz and Mar{\'i}a Pilar Sepulcre and Diana Garc{\'i}a-Moreno and Inmaculada Fuentes and Julia B{\'e}jar and Manuel Manchado and Mar{\'i}a del Carmen Alvarez and Jose Jaime Meseguer and Victoriano Mulero},
  journal={Developmental and comparative immunology},
  year={2012},
  volume={37 3-4},
  pages={429-37}
}
The viral nervous necrosis virus (VNNV) is the causal agent of viral encephalopathy and retinopathy (VER), a worldwide fish disease that is responsible for high mortality in both marine and freshwater species. Infected fish suffer from encephalitis, which leads to abnormal swimming behavior and extensive cellular vacuolation and neuronal degeneration in the central nervous system (CNS) and retina. The marine fish gilthead seabream (Sparus aurata) does not develop VER but it is an asymptomatic… CONTINUE READING