Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study

@article{Josefsson2000ViralLO,
  title={Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study},
  author={Andreas Josefsson and Patrik K E Magnusson and Nathalie Ylitalo and Per Hvidkj{\ae}r S\orensen and P Qwarforth-Tubbin and Per Kragh Andersen and Mads Melbye and Hans Olov Adami and Ulf Gyllensten},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={2189-2193}
}
BACKGROUND Infection with certain types of human papillomavirus (HPV), which is common among young women, increases the risk of cervical cancer. However, less than 1% of young women positive for oncogenic types of HPV develop cervical cancer. We investigated whether the amount of HPV DNA is a useful predictor of progression to cervical carcinoma in situ. METHODS We estimated the amount of HPV 16 DNA by a PCR that uses the 5'-exonuclease (Taqman) method, in 478 women with cervical carcinoma in… CONTINUE READING
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