Viral load and neuropathology in the SIV model.

@article{Boche1999ViralLA,
  title={Viral load and neuropathology in the SIV model.},
  author={D Boche and Emmanuel Khatissian and Françoise Gray and Pierre Barth{\'e}l{\'e}my Falanga and Luc Montagnier and Bruno Hurtrel},
  journal={Journal of neurovirology},
  year={1999},
  volume={5 3},
  pages={232-40}
}
To investigate neuropathological processes involved in HIV infection, a longitudinal analysis of central nervous system (CNS) changes was performed using the SIV-infected macaque model. Five animals were studied during the early phase and 13 during the asymptomatic and symptomatic phases. Histopathological analyses were performed on one cerebral fixed hemisphere whereas on the other frozen hemisphere in situ hybridisation, immunohistochemistry and RT-PCR were performed. Viral load was… CONTINUE READING

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