Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection.

@article{Robinson2012ViralIR,
  title={Viral interferon regulatory factors are critical for delay of the host immune response against rhesus macaque rhadinovirus infection.},
  author={Bridget Robinson and Megan A O'Connor and He Li and Flora Engelmann and Britt Poland and Richard Grant and Victor R Defilippis and Ryan D. Estep and Michael K Axthelm and Ilhem Messaoudi and Scott W. Wong},
  journal={Journal of virology},
  year={2012},
  volume={86 5},
  pages={2769-79}
}
Kaposi's sarcoma-associated herpesvirus (KSHV) and the closely related gamma-2 herpesvirus rhesus macaque (RM) rhadinovirus (RRV) are the only known viruses to encode viral homologues of the cellular interferon (IFN) regulatory factors (IRFs). Recent characterization of a viral IRF (vIRF) deletion clone of RRV (vIRF-knockout RRV [vIRF-ko RRV]) demonstrated that vIRFs inhibit induction of type I and type II IFNs during RRV infection of peripheral blood mononuclear cells. Because the IFN response… CONTINUE READING