Viral interactions with the blood-brain barrier: old dog, new tricks.

@article{Hou2016ViralIW,
  title={Viral interactions with the blood-brain barrier: old dog, new tricks.},
  author={Jianghui Hou and Lane A Baker and Lushan Zhou and Robyn S Klein},
  journal={Tissue barriers},
  year={2016},
  volume={4 1},
  pages={e1142492}
}
Brain endothelial cells form a unique cellular structure known as the tight junction to regulate the exchanges between the blood and the parenchyma by limiting the paracellular diffusion of blood-borne substance. Together with the restricted pathway of transcytosis, the tight junction in the brain endothelial cells provides the central nervous system (CNS) with effective protection against both the foreign pathogens and the host immune cells, which is also termed the "blood-brain barrier." The… CONTINUE READING

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