Viral interaction: a possible contributing factor in head and neck cancer progression

@article{Underbrink2008ViralIA,
  title={Viral interaction: a possible contributing factor in head and neck cancer progression},
  author={Michael P Underbrink and Stephen L. Hoskins and Anna Maria Pou and Thomas Albrecht},
  journal={Acta Oto-Laryngologica},
  year={2008},
  volume={128},
  pages={1361 - 1369}
}
Conclusion. Human herpesvirus-8 could potentiate the effects of human papillomavirus (HPV)-16 on cell cycle dysregulation by up-regulating the transcription of HPV-16 E7, which can lead to malignant transformation of normal epithelial cells. Objectives. High-risk HPV-16 is known for its association with development of head and neck carcinoma, leading to considerable morbidity and mortality worldwide. HPV-16 produces two early proteins, E6 and E7, that can disrupt the cell cycle and transform… 

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