Viral infection and dissemination through the olfactory pathway and the limbic system by Theiler's virus.

@article{Wada1993ViralIA,
  title={Viral infection and dissemination through the olfactory pathway and the limbic system by Theiler's virus.},
  author={Yoshiaki Wada and Robert Shin Fujinami},
  journal={The American journal of pathology},
  year={1993},
  volume={143 1},
  pages={221-9}
}
Theiler's murine encephalomyelitis virus (TMEV) infection of mice can produce a biphasic disease of the central nervous system (CNS). Most susceptible strains of mice survive the acute infection and develop a chronic demyelinating disease. In this report, we analyzed the routes of spread of TMEV within the CNS of nude mice and target sites eventually infected in the CNS. Compared to the immunocompetent mouse, in which an antiviral immune response is mounted but virus persists, the nude mouse… CONTINUE READING

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