Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors.

@article{Garoufalis1994ViralIO,
  title={Viral induction of the human beta interferon promoter: modulation of transcription by NF-kappa B/rel proteins and interferon regulatory factors.},
  author={E Garoufalis and Irene S. Y. Kwan and Rongtuan Lin and Amir Mustafa and Nicholas Pepin and Anne Roulston and J. R. Collet Lacoste and John Hiscott},
  journal={Journal of virology},
  year={1994},
  volume={68 8},
  pages={4707-15}
}
Multiple regulatory domains within the -100 region of the beta interferon (IFN-beta) promoter control the inducible response of the IFN gene to virus infection. In this study, we demonstrate that the formation of NF-kappa B-specific complexes on the positive regulatory domain II (PRDII) precedes the onset of detectable IFN-beta transcription in Sendai virus-infected cells. By using NF-kappa B subunit-specific antibodies, a temporal shift in the composition of NF-kappa B subunits in association… CONTINUE READING

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